Cardiovascular event in a cohort of rheumatoid arthritis patients in Castilla-La Mancha: Utility of carotid ultrasound.
Reumatol Clin (Engl Ed)
; 20(3): 150-154, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38443230
ABSTRACT
Rheumatoid Arthritis (RA) has a mortality rate 1,3 to 3 times higher than the general population, with cardiovascular mortality accounting for 40-50% of cases. Currently, cardiovascular disease is considered an extraarticular manifestation of RA (OR 1,5-4,0). Ultrasound measurement of the intima-media thickness (IMT) of the common carotid artery and the presence of atherosclerotic plaques (AP) is a non-invasive method and a surrogate marker of subclinical arteriosclerosis. OBJECTIVE:
To determine if subclinical arteriosclerosis findings through carotid ultrasound can serve as a good predictor of cardiovascular events (CVE) development in a cohort of RA patients over a 10-year period.METHODOLOGY:
A cohort of RA patients seen in the Rheumatology outpatient clinic of a hospital in Castilla La Mancha in 2013 was evaluated. A prospective evaluation for the development of CVE over the following 10 years was conducted, and its correlation with previous ultrasound findings of IMT and AP was analyzed.RESULTS:
Eight (24%) patients experienced a CVE. Three (9%) had heart failure, three (9%) had a stroke, and two (6%) experienced acute myocardial infarction. RA patients who developed a CVE had a higher IMT (0,97 +/- 0.08â¯mm) compared to the RA patients without CV complications (0,74 +/- 0.15â¯mm) (pâ¯=â¯0,003). The presence of IMTâ¯≥â¯0.9â¯mm and AP had a relative risk of 12,25 (pâ¯=â¯0,012) and 18,66 (pâ¯=â¯0,003), respectively, for the development of a CVE.CONCLUSIONS:
Carotid ultrasound in RA patients may allow for early detection of subclinical atherosclerosis before the development of CVE, with IMTâ¯≥â¯0.9â¯mm being the most closely associated finding with CVE, unaffected by age.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Doenças Cardiovasculares
/
Aterosclerose
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article