Exploring the causal relationship between antihypertensive drugs and glioblastoma by combining drug target Mendelian randomization study, eQTL colocalization, and single-cell RNA sequencing.

Zhao, Songyun; Xie, Yi; Ding, Xu; Zheng, Chuanhua; Chen, Jiaxing; Zhao, Ning; Ji, Yi; Wang, Qi; Liu, Yuankun; Cheng, Chao

Zhao, Songyun; Xie, Yi; Ding, Xu; Zheng, Chuanhua; Chen, Jiaxing; Zhao, Ning; Ji, Yi; Wang, Qi; Liu, Yuankun; Cheng, Chao.

Afiliação

Zhao S; Department of Neurosurgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Xie Y; Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
Ding X; Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Zheng C; Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
Chen J; Department of Neurosurgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Zhao N; Department of Neurosurgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Ji Y; Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
Wang Q; Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
Liu Y; Department of Gastroenterology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Cheng C; Department of Neurosurgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

Environ Toxicol ; 39(6): 3425-3433, 2024 Jun.

Article em En | MEDLINE | ID: mdl-38450887

Assuntos

Anti-Hipertensivos; Estudo de Associação Genômica Ampla; Glioblastoma; Análise da Randomização Mendeliana; Polimorfismo de Nucleotídeo Único; Receptores Adrenérgicos beta 1; Glioblastoma/genética; Glioblastoma/tratamento farmacológico; Humanos; Anti-Hipertensivos/uso terapêutico; Receptores Adrenérgicos beta 1/genética; Locos de Características Quantitativas; Pressão Sanguínea/efeitos dos fármacos; Análise de Sequência de RNA; Análise de Célula Única; Antagonistas Adrenérgicos beta/uso terapêutico; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/tratamento farmacológico

Palavras-chave

ADRB1; Mendelian randomization; antihypertensive drugs; eQTL; glioblastoma; scRNAseq

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos beta 1 / Glioblastoma / Polimorfismo de Nucleotídeo Único / Estudo de Associação Genômica Ampla / Análise da Randomização Mendeliana / Anti-Hipertensivos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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