Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?
Transfusion
; 64 Suppl 2: S11-S13, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38461482
ABSTRACT
Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely related to a combination of bleeding reduction and other non-bleeding effects. If TXA is given more than 3 h after traumatic injury, there is a significant and paradoxical increased risk of death due to bleeding. TXA has level 1 evidence for use as a bleeding reduction agent in isolated orthopedic operations, but in polytrauma patients undergoing orthopedic operations, it is not clear if and when TXA is safe or effective once outside the 3-h window of proven trauma efficacy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Tranexâmico
/
Ferimentos e Lesões
/
Hemorragia
/
Antifibrinolíticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article