Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan.

Borland, Gillian; Wilkie, Stephen E; Thomson, Jackie; Wang, Zhe; Tullet, Jennifer M A; Alic, Nazif; Selman, Colin

Borland, Gillian; Wilkie, Stephen E; Thomson, Jackie; Wang, Zhe; Tullet, Jennifer M A; Alic, Nazif; Selman, Colin.

Afiliação

Borland G; School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Wilkie SE; School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Thomson J; School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Wang Z; School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Tullet JMA; Faculty of Natural Sciences, University of Kent, Canterbury, UK.
Alic N; Department of Genetics Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
Selman C; School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.

Aging Cell ; 23(5): e14141, 2024 05.

Article em En | MEDLINE | ID: mdl-38465473

Assuntos

Envelhecimento; Heterozigoto; Longevidade; RNA Polimerase III; Animais; Feminino; Masculino; Camundongos; Envelhecimento/genética; Longevidade/genética; Camundongos Endogâmicos C57BL; RNA Polimerase III/genética; RNA Polimerase III/metabolismo

Palavras-chave

Aging; C57BL/6N; RNA polymerase III; healthspan; longevity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Polimerase III / Envelhecimento / Heterozigoto / Longevidade Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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