Long-term sorbitol consumption affects the hippocampus and alters cognitive function in aged mice.
Genes Cells
; 29(5): 432-437, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38467515
ABSTRACT
The systemic effects of the artificial sweetener sorbitol on older adult individuals have not been elucidated. We assessed the effects of sorbitol consumption on cognitive and gingival health in a mouse model. Aged mice were fed 5% sorbitol for 3 months before their behavior was assessed, and brain and gingival tissues were collected. Long-term sorbitol consumption inhibited gingival tissue aging in aged mice. However, it caused cognitive decline and decreased brain-derived neurotrophic factor (BDNF) in the hippocampus. Sorbitol consumption did not affect homeostatic function; however, it may exert effects within the brain, particularly in the hippocampus.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sorbitol
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Envelhecimento
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Cognição
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Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article