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HLA Genetics for the Human Diseases.
Shiina, Takashi; Kulski, Jerzy K.
Afiliação
  • Shiina T; Tokai University School of Medicine, Isehara, Japan. tshiina@is.icc.u-tokai.ac.jp.
  • Kulski JK; Tokai University School of Medicine, Isehara, Japan.
Adv Exp Med Biol ; 1444: 237-258, 2024.
Article em En | MEDLINE | ID: mdl-38467984
ABSTRACT
Highly polymorphic human leukocyte antigen (HLA) molecules (alleles) expressed by different classical HLA class I and class II genes have crucial roles in the regulation of innate and adaptive immune responses, transplant rejection and in the pathogenesis of numerous infectious and autoimmune diseases. To date, over 35,000 HLA alleles have been published from the IPD-IMGT/HLA database, and specific HLA alleles and HLA haplotypes have been reported to be associated with more than 100 different diseases and phenotypes. Next generation sequencing (NGS) technology developed in recent years has provided breakthroughs in various HLA genomic/gene studies and transplant medicine. In this chapter, we review the current information on the HLA genomic structure and polymorphisms, as well as the genetic context in which numerous disease associations have been identified in this region.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe I / Antígenos HLA Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe I / Antígenos HLA Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article