Antinociceptive iridoid glycosides from the aerial parts of Paederia foetida.
J Asian Nat Prod Res
; 26(7): 788-794, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38469737
ABSTRACT
Two previously undescribed iridoid glycosides, 6'-O-trans-feruloyl-(4S,6R)-3,4-dihydro-3ß-ethoxypaederoside (1) and 6'-O-trans-caffeoyl-(4S,6R)-3,4-dihydro-2'-O-3α-paederoside (2), were isolated from the 90% EtOH extract of the air dried aerial parts of Paederia Foetida. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested in vivo for their antinociceptive properties. As a result, 2 showed potent antinociceptive effect and its ID50 value (53.4 µmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Componentes Aéreos da Planta
/
Glicosídeos Iridoides
/
Analgésicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article