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Metal-free ß,γ-C(sp3)-H difunctionalization of propanols: DMP-initiated asymmetric spirocyclopropanation.
Li, Zheyao; Zhang, Huiwen; Zhao, Lin; Ma, Yueyue; Wu, Qiufang; Ren, Haosong; Lin, Zhongren; Zheng, Jun; Yu, Xinhong.
Afiliação
  • Li Z; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jz@ec
  • Zhang H; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jz@ec
  • Zhao L; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jz@ec
  • Ma Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, 100 West Waihuan Road, Guangzhou 510006, Guangdong, China. mayueyue20121@gdut.edu.cn.
  • Wu Q; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jz@ec
  • Ren H; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jz@ec
  • Lin Z; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jz@ec
  • Zheng J; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jz@ec
  • Yu X; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jz@ec
Chem Commun (Camb) ; 60(26): 3579-3582, 2024 Mar 26.
Article em En | MEDLINE | ID: mdl-38470069
ABSTRACT
A DMP-initiated metal-free effective ß,γ-asymmetric spirocyclopropanation of propanols strategy using oxidative iminium activation is described. This process has been realized by a synergistic amine-catalyzed one-pot cascade oxidation-Michael addition cyclopropanation for "one-pot" access to various spirocyclopropyl propionaldehydes/propanols from diverse 3-arylpropanols and α-brominated active methylene compounds under mild conditions and with high enantioselectivity (ee up to >99%).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article