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P2X7 Receptor in Dendritic Cells and Macrophages: Implications in Antigen Presentation and T Lymphocyte Activation.
Acuña-Castillo, Claudio; Escobar, Alejandro; García-Gómez, Moira; Bachelet, Vivienne C; Huidobro-Toro, Juan Pablo; Sauma, Daniela; Barrera-Avalos, Carlos.
Afiliação
  • Acuña-Castillo C; Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.
  • Escobar A; Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.
  • García-Gómez M; Laboratorio Biología Celular y Molecular, Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago 8380000, Chile.
  • Bachelet VC; Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, Chile.
  • Huidobro-Toro JP; Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9160000, Chile.
  • Sauma D; Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.
  • Barrera-Avalos C; Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, Chile.
Int J Mol Sci ; 25(5)2024 Feb 21.
Article em En | MEDLINE | ID: mdl-38473744
ABSTRACT
The P2X7 receptor, a member of the P2X purinergic receptor family, is a non-selective ion channel. Over the years, it has been associated with various biological functions, from modulating to regulating inflammation. However, its emerging role in antigen presentation has captured the scientific community's attention. This function is essential for the immune system to identify and respond to external threats, such as pathogens and tumor cells, through T lymphocytes. New studies show that the P2X7 receptor is crucial for controlling how antigens are presented and how T cells are activated. These studies focus on antigen-presenting cells, like dendritic cells and macrophages. This review examines how the P2X7 receptor interferes with effective antigen presentation and activates T cells and discusses the fundamental mechanisms that can affect the immune response. Understanding these P2X7-mediated processes in great detail opens up exciting opportunities to create new immunological therapies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apresentação de Antígeno / Receptores Purinérgicos P2X7 Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apresentação de Antígeno / Receptores Purinérgicos P2X7 Idioma: En Ano de publicação: 2024 Tipo de documento: Article