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Genomic Regions and Candidate Genes Affecting Response to Heat Stress with Newcastle Virus Infection in Commercial Layer Chicks Using Chicken 600K Single Nucleotide Polymorphism Array.
Wang, Ying; Saelao, Perot; Chanthavixay, Ganrea; Gallardo, Rodrigo A; Wolc, Anna; Fulton, Janet E; Dekkers, Jack M; Lamont, Susan J; Kelly, Terra R; Zhou, Huaijun.
Afiliação
  • Wang Y; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.
  • Saelao P; Department of Animal Science, University of California, Davis, CA 95616, USA.
  • Chanthavixay G; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.
  • Gallardo RA; Department of Animal Science, University of California, Davis, CA 95616, USA.
  • Wolc A; Veterinary Pest Genetics Research Unit, United States Department of Agriculture U, Kerrville, TX 78006, USA.
  • Fulton JE; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.
  • Dekkers JM; Department of Animal Science, University of California, Davis, CA 95616, USA.
  • Lamont SJ; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.
  • Kelly TR; School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
  • Zhou H; Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
Int J Mol Sci ; 25(5)2024 Feb 24.
Article em En | MEDLINE | ID: mdl-38473888
ABSTRACT
Heat stress results in significant economic losses to the poultry industry. Genetics plays an important role in chickens adapting to the warm environment. Physiological parameters such as hematochemical parameters change in response to heat stress in chickens. To explore the genetics of heat stress resilience in chickens, a genome-wide association study (GWAS) was conducted using Hy-Line Brown layer chicks subjected to either high ambient temperature or combined high temperature and Newcastle disease virus infection. Hematochemical parameters were measured during three treatment phases acute heat stress, chronic heat stress, and chronic heat stress combined with NDV infection. Significant changes in blood parameters were recorded for 11 parameters (sodium (Na+, potassium (K+), ionized calcium (iCa2+), glucose (Glu), pH, carbon dioxide partial pressure (PCO2), oxygen partial pressure (PO2), total carbon dioxide (TCO2), bicarbonate (HCO3), base excess (BE), and oxygen saturation (sO2)) across the three treatments. The GWAS revealed 39 significant SNPs (p < 0.05) for seven parameters, located on Gallus gallus chromosomes (GGA) 1, 3, 4, 6, 11, and 12. The significant genomic regions were further investigated to examine if the genes within the regions were associated with the corresponding traits under heat stress. A candidate gene list including genes in the identified genomic regions that were also differentially expressed in chicken tissues under heat stress was generated. Understanding the correlation between genetic variants and resilience to heat stress is an important step towards improving heat tolerance in poultry.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Galinhas / Doença de Newcastle Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Galinhas / Doença de Newcastle Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article