Construction of a prognostic model based on genome-wide methylation analysis of miRNAs for hepatocellular carcinoma.
Epigenomics
; 2024 Mar 13.
Article
em En
| MEDLINE
| ID: mdl-38477016
ABSTRACT
Aim:
Using the methylation level of miRNA genes to develop a prognostic model for patients with hepatocellular carcinoma (HCC). Materials &methods:
least absolute shrinkage and selection operator and multivariate Cox regression analyses were performed to develop a prognostic model. One miRNA in the model was selected for verification.Results:
A prognostic model was developed using eight miRNAs. The areas under the curve for predicting overall survival at 1, 3 and 5 years were 0.75, 0.81 and 0.81. miR-223 was found to be hypomethylated in 160 HCC tissues, and its methylation level was associated with Barcelona Clinic Liver Cancer stages and the prognosis of patients with HCC.Conclusion:
The prognostic model based on miRNA methylation levels has the capability to partially forecast the prognosis of patients with HCC.
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article