Idiopathic chronic intestinal pseudo-obstruction syndrome is strongly associated with low serum levels of vitamin D.
Eur J Gastroenterol Hepatol
; 36(5): 584-587, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38477850
ABSTRACT
Idiopathic chronic intestinal pseudo-obstruction (CIPO) is associated with intestinal inflammation and malabsorption and may cause serum vitamin D deficiency. We aimed to assess whether there is an association between idiopathic CIPO and serum levels of 25-hydroxy-vitamin D. Consecutive patients with confirmed diagnosis of idiopathic CIPO were prospectively enrolled and matched with healthy controls by gender, age, and BMI. Median serum level of 25-hydroxy-vitamin D of patients with CIPO was compared with that of healthy subjects using the Wilcoxon signed-rank test for matched samples. A total of 35 patients with CIPO and 35 matched healthy subjects were enrolled. All patients with CIPO had a 25-hydroxy-vitamin D deficiency with serum levels <12â
ng/ml. The median serum level of vitamin D was significantly lower in patients with CIPO than in healthy controls (5.7 vs. 29.7â
ng/ml, P â
<â
0.0001). Serum level of vitamin D was not associated with gender ( P â
=â
0.27), age ( P â
=â
0.22), BMI ( P â
=â
0.95), high (>10â
000â
×â
ml) WBC count ( P â
=â
0.08), or high (>5â
mg/l) C-reactive protein ( P â
=â
0.87) among patients with CIPO. CIPO seems to be strongly associated with low serum levels of 25-hydroxy-vitamin D.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina D
/
Pseudo-Obstrução Intestinal
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article