[Endocarditis and ischemic stroke of rare cause]. / Endokarditis und ischämischer Apoplex mit seltener Ursache.
Inn Med (Heidelb)
; 65(8): 840-842, 2024 Aug.
Article
em De
| MEDLINE
| ID: mdl-38483553
ABSTRACT
A 60-year-old male patient presented with ischemic-embolic stroke. Transesophageal echocardiography revealed the cause to be aortic valve endocarditis with highly eccentric aortic valve regurgitation. The blood cultures taken several times remained sterile. The indication for surgical aortic valve replacement was made. Conventional microbiological work-up of the heart valve did not reveal any pathogens. The additional molecular genetic testing using eubacterial PCR ("polymerase chain reaction" [PCR]) finally demonstrated the presence of Tropheryma whipplei. A number of therapeutic options were available. The authors decided on intravenous antibiotic therapy with ceftriaxone for 14 days and follow-up therapy with oral trimethoprim/sulfamethoxazole for 1 year. The case illustrates the importance of additional molecular diagnostics beyond the conventional methods in blood culture-negative endocarditis to identify the pathogen and initiate appropriate therapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endocardite Bacteriana
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AVC Isquêmico
Limite:
Humans
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Male
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Middle aged
Idioma:
De
Ano de publicação:
2024
Tipo de documento:
Article