A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle.
Genes Dev
; 38(3-4): 95-97, 2024 03 22.
Article
em En
| MEDLINE
| ID: mdl-38485266
ABSTRACT
Metabolic reprogramming of stem cells is a targetable pathway to control regeneration. Activation of stem cells results in down-regulation of oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) and turns on glycolysis to provide fuel for proliferation and specific signaling events. How cell type-specific events are regulated is unknown. In this issue of Genes & Development Ciuffoli and colleagues (pp. 151-167) use metabolomic, gene inactivation, and functional approaches to show that phosphoserine aminotransferase (Psat1), an enzyme in serine biosynthesis, is activated in muscle stem cells and contributes to cell expansion and skeletal muscle regeneration via the production of α-ketoglutarate and glutamine.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Células Satélites de Músculo Esquelético
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article