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Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis.
Saeed, Maria; Aitken, Elizabeth H; Rogerson, Stephen J.
Afiliação
  • Saeed M; Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
  • Aitken EH; Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
  • Rogerson SJ; Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Department of Medicine, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia. Electronic address: sroger@unimelb.edu.au.
Trends Parasitol ; 40(4): 278-279, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38485580
ABSTRACT
Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesão Pulmonar Aguda / Armadilhas Extracelulares / Malária Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesão Pulmonar Aguda / Armadilhas Extracelulares / Malária Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article