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Effects of Prune (Dried Plum) Supplementation on Cardiometabolic Health in Postmenopausal Women: An Ancillary Analysis of a 12-Month Randomized Controlled Trial, The Prune Study.
Damani, Janhavi J; Rogers, Connie J; Lee, Hang; Strock, Nicole Ca; Koltun, Kristen J; Williams, Nancy I; Weaver, Connie; Ferruzzi, Mario G; Nakatsu, Cindy H; De Souza, Mary Jane.
Afiliação
  • Damani JJ; The Intercollege Graduate Degree Program in Integrative and Biomedical Physiology, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, United States; Department of Kinesiology, The Pennsylvania State University, University Park, PA, United States.
  • Rogers CJ; Department of Nutritional Sciences, University of Georgia, Athens, GA, United States.
  • Lee H; Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
  • Strock NC; Department of Kinesiology, The Pennsylvania State University, University Park, PA, United States.
  • Koltun KJ; Department of Kinesiology, The Pennsylvania State University, University Park, PA, United States; Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, United States.
  • Williams NI; Department of Kinesiology, The Pennsylvania State University, University Park, PA, United States.
  • Weaver C; School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, United States.
  • Ferruzzi MG; Arkansas Children's Nutrition Center, Department of Pediatrics, University of Arkansas for Medical Science, Little Rock, AR, United States.
  • Nakatsu CH; Department of Agronomy, Purdue University, West Lafayette, IN, United States.
  • De Souza MJ; Department of Kinesiology, The Pennsylvania State University, University Park, PA, United States. Electronic address: mjd34@psu.edu.
J Nutr ; 154(5): 1604-1618, 2024 05.
Article em En | MEDLINE | ID: mdl-38490532
ABSTRACT

BACKGROUND:

Estrogen withdrawal during menopause is associated with an unfavorable cardiometabolic profile. Prunes (dried plums) represent an emerging functional food and have been previously demonstrated to improve bone health. However, our understanding of the effects of daily prune intake on cardiometabolic risk factors in postmenopausal women is limited.

OBJECTIVES:

We conducted an ancillary investigation of a randomized controlled trial (RCT), The Prune Study, to evaluate the effect of 12-mo prune supplementation on cardiometabolic health markers in postmenopausal women.

METHODS:

The Prune Study was a single-center, parallel-design, 12-mo RCT in which postmenopausal women were allocated to no-prune control, 50 g/d prune, or 100 g/d prune groups. Blood was collected at baseline, 6 mo, and 12 mo/post to measure markers of glycemic control and blood lipids. Body composition was assessed at baseline, 6 mo, and 12 mo/post using dual-energy X-ray absorptiometry. Linear mixed-effects models were used to evaluate the effect of time, treatment, and their interaction on cardiometabolic health markers, all quantified as exploratory outcomes.

RESULTS:

A total of 183 postmenopausal women (mean age, 62.1 ± 4.9 y) completed the entire 12-mo RCT control (n = 70), 50 g/d prune (n = 67), and 100 g/d prune (n = 46). Prune supplementation at 50 g/d or 100 g/d did not alter markers of glycemic control and blood lipids after 12 mo compared with the control group (all P > 0.05). Furthermore, gynoid percent fat and visceral adipose tissue (VAT) indices did not significantly differ in women consuming 50 g/d or 100 g/d prunes compared with the control group after 12 mo of intervention. However, android total mass increased by 3.19% ± 5.5% from baseline in the control group, whereas the 100 g/d prune group experienced 0.02% ± 5.6% decrease in android total mass from baseline (P < 0.01).

CONCLUSIONS:

Prune supplementation at 50 g/d or 100 g/d for 12 mo does not improve glycemic control and may prevent adverse changes in central adiposity in postmenopausal women. This trial was registered at clinicaltrials.gov as NCT02822378.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pós-Menopausa / Suplementos Nutricionais Limite: Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pós-Menopausa / Suplementos Nutricionais Limite: Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article