From a bimodal to a multi-stage view on trypanosomes' differential RNA editing.

Zamani, Homa; Poorinmohammad, Naghmeh; Azimi, Amin; Salavati, Reza

Zamani, Homa; Poorinmohammad, Naghmeh; Azimi, Amin; Salavati, Reza.

Afiliação

Zamani H; Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3V9, Canada.
Poorinmohammad N; Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3V9, Canada.
Azimi A; Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3V9, Canada.
Salavati R; Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3V9, Canada; Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada. Electronic address: reza.salavati@mcgill.ca.

Trends Parasitol ; 40(5): 372-377, 2024 May.

Article em En | MEDLINE | ID: mdl-38494388

ABSTRACT

ABSTRACT

Significant variations in the abundance of mitochondrial RNA processing proteins and their target RNAs across trypanosome life stages present an opportunity to explore the regulatory mechanisms that drive these changes. Utilizing omics approaches can uncover unconventional targets, aiding our understanding of the parasites' adaptation and enabling targeted interventions for differentiation.

Assuntos

Edição de RNA; Trypanosoma; Trypanosoma/genética; Estágios do Ciclo de Vida/genética; RNA de Protozoário/genética; RNA de Protozoário/metabolismo; Proteínas de Protozoários/metabolismo; Proteínas de Protozoários/genética

Palavras-chave

RNA editing; RNA editing machinery dynamics; omics approaches in parasite adaptation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma / Edição de RNA Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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