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Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysis.
Zhou, Chunbin; Balmer, Lois; Song, Manshu; Mahara, Gehendra; Wu, Kezhou; Wang, Wei; Wang, Hu.
Afiliação
  • Zhou C; Center for Precision Health, School of Medical and Health Science, Edith Cowan University, Perth, WA, 6027, Australia.
  • Balmer L; Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
  • Song M; Center for Precision Health, School of Medical and Health Science, Edith Cowan University, Perth, WA, 6027, Australia.
  • Mahara G; Center for Precision Health, School of Medical and Health Science, Edith Cowan University, Perth, WA, 6027, Australia.
  • Wu K; Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
  • Wang W; Department of Cardiovascular Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
  • Wang H; Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
Noncoding RNA Res ; 9(2): 341-349, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38505307
ABSTRACT
Circular RNAs (circRNAs) play a crucial role in cancer development and progression. This study aimed to identify potential circRNA biomarkers for osteosarcoma. Articles published from January 2010 to September 2023 were searched across eight databases to compare circRNA expression profiles in osteosarcoma and control samples (human, animal and cell lines). Meta-analysis was conducted under a random effects model. Subgroup analysis of circRNAs in different samples and tissues was performed. Diagnostic value was evaluated using receiver operator characteristic curves. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis explored functions of circRNA host genes. A circRNA-miRNA-mRNA axis depicted the regulatory mechanism in osteosarcoma. Among 1356 circRNAs with differential expression were identified across 226 original studies, only 74 were reported in at least three published sub-studies. Meta-analysis identified 58 dysregulated circRNAs (52 upregulated and 6 downregulated). Eleven circRNAs consistently showed dysregulation in tissues and cell lines, with hsa_circ_0005721 showing potential as a circulating biomarker in osteosarcoma. Sensitivity analysis demonstrated 97 % consistency. The overall area under the curve was 0.87 (95 % CI, 0.83-0.89). GO and KEGG enrichment analyses revealed host gene involvement in cancer. The circRNA-miRNA-mRNA axis revealed the regulatory axis and interactions within osteosarcoma specifically. This study demonstrates circRNAs as potential diagnostic biomarkers for osteosarcoma. Consistently reported dysregulated circRNAs are potential biomarkers in osteosarcoma pathogenesis, with hsa_circ_0005721 as a potential circulating biomarker for diagnosis and treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article