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Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma.
Du, Wenyi; Yan, Chen; Wang, Yinkang; Song, Chen; Li, Yunfan; Tian, Zhiqiang; Liu, Yuan; Shen, Wei.
Afiliação
  • Du W; Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
  • Yan C; Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
  • Wang Y; Medical Imaging Centre, Tengzhou Central People's Hospital, Jining Medical College, Shandong, China.
  • Song C; Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
  • Li Y; Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
  • Tian Z; Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
  • Liu Y; Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
  • Shen W; Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Lipids Health Dis ; 23(1): 82, 2024 Mar 20.
Article em En | MEDLINE | ID: mdl-38509591
ABSTRACT

BACKGROUND:

Dyslipidemia and abnormalities in cholesterol metabolism are commonly observed in individuals with gallstone disease. Previous research has demonstrated that dietary magnesium can influence lipid metabolism. The atherogenic index of plasma (AIP) has emerged as a novel lipid marker. This study aimed to examine the possible correlation between dietary magnesium intake and gallstones and the potential mediating role of AIP in US adults.

METHODS:

A total of 4,841 adults were included in this study from the National Health and Nutrition Examination Survey (NHANES) conducted from 2017 to 2020. A variety of statistical techniques such as logistic regression, subgroup analysis, smoothed curve fitting, and causal mediation analysis were utilized to analyze the information collected from the participants.

RESULTS:

In the fully adjusted model, a statistically noteworthy inverse relationship was observed between dietary magnesium intake and the presence of gallstones, as indicated by an odds ratio (OR) of 0.58 and a 95% confidence interval (CI) of (0.42, 0.81). Causal intermediary analysis revealed that the association between magnesium intake and gallstones was partially mediated by AIP, with a mediation ratio of 3.2%.

CONCLUSION:

According to this study, dietary magnesium intake had a significant linear negative association with the prevalence of gallstones, in which AIP played a mediating role. This discovery offers novel perspectives on the prevention and management of gallstones.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálculos Biliares / Aterosclerose Limite: Adult / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálculos Biliares / Aterosclerose Limite: Adult / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article