Synthesis and inâ
vitro Anti-Inflammatory Activity of Novel Dendrobine Amide/Sulfonamide Derivatives.
Chem Biodivers
; 21(5): e202400030, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38511964
ABSTRACT
A traditional Chinese medicine ingredient, dendrobine, has been demonstrated to have anti-inflammatory properties. However, due to its poor anti-inflammatory properties, its clinical use is limited. Consequently, we have designed and synthesized 32 new amide/sulfonamide dendrobine derivatives and screened their anti-inflammatory activities inâ
vitro. Experiments showed that nitric oxide (NO) generation in lipopolysaccharide (LPS)-induced RAW264.7 cells was strongly reduced by derivative 14, with an IC50 of 2.96â
µM. Western blot research revealed that 14 decreased the concentration-dependent expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (INOS). Molecular docking was used to predict the binding of the inflammation-associated proteins COX-2 and INOS to compound 14.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Lipopolissacarídeos
/
Ciclo-Oxigenase 2
/
Óxido Nítrico Sintase Tipo II
/
Simulação de Acoplamento Molecular
/
Amidas
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article