Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review).
Int J Mol Med
; 53(5)2024 May.
Article
em En
| MEDLINE
| ID: mdl-38516776
ABSTRACT
Circular RNAs (circRNAs) are noncoding singlestranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and posttranscriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy. In addition, novel potential interactions between circRNAs expressed in renal cells exposed to highglucose concentrations and the transcription factors cJun and cFos are reported.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus
/
Nefropatias Diabéticas
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article