Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review).

ABSTRACT

Circular RNAs (circRNAs) are non­coding single­stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post­transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy. In addition, novel potential interactions between circRNAs expressed in renal cells exposed to high­glucose concentrations and the transcription factors c­Jun and c­Fos are reported.