Split Proteins and Reassembly Modules for Biological Applications.
Chembiochem
; 25(10): e202400123, 2024 May 17.
Article
em En
| MEDLINE
| ID: mdl-38530024
ABSTRACT
Split systems, modular entities enabling controlled biological processes, have become instrumental in biological research. This review highlights their utility across applications like gene regulation, protein interaction identification, and biosensor development. Covering significant progress over the last decade, it revisits traditional split proteins such as GFP, luciferase, and inteins, and explores advancements in technologies like Cas proteins and base editors. We also examine reassembly modules and their applications in diverse fields, from gene regulation to therapeutic innovation. This review offers a comprehensive perspective on the recent evolution of split systems in biological research.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas Biossensoriais
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article