The je ne sais quoi of 5-methylcytosine in messenger RNA.
RNA
; 30(5): 560-569, 2024 Apr 16.
Article
em En
| MEDLINE
| ID: mdl-38531644
ABSTRACT
The potential presence of 5-methylcytosine as a sparse internal modification of mRNA was first raised in 1975, and a first map of the modification was also part of the epitranscriptomics "big bang" in 2012. Since then, the evidence for its presence in mRNA has firmed up, and initial insights have been gained into the molecular function and broader biological relevance of 5-methylcytosine when present in mRNA. Here, we summarize the status quo of the field, outline some of its current challenges, and suggest how to address them in future work.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA
/
5-Metilcitosina
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article