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High frequency of circulating non-classical monocytes is associated with stable remission in relapsing-remitting multiple sclerosis.
Minote, Misako; Sato, Wakiro; Kimura, Kimitoshi; Kimura, Atsuko; Lin, Youwei; Okamoto, Tomoko; Takahashi, Ryosuke; Yamamura, Takashi.
Afiliação
  • Minote M; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Sato W; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kimura K; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Kimura A; Multiple Sclerosis Center, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Lin Y; Section of Research and Development Strategy, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Okamoto T; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Takahashi R; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Yamamura T; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Immunol Med ; 47(3): 151-165, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38539051
ABSTRACT
'No evidence of disease activity (NEDA)', judged by clinical and radiological findings, is a therapeutic goal in patients with multiple sclerosis (MS). It is, however, unclear if distinct biological mechanisms contribute to the maintenance of NEDA. To clarify the immunological background of long-term disease stability defined by NEDA, circulating immune cell subsets in patients with relapsing-remitting MS (RRMS) were analyzed using flow cytometry. Patients showing long-term NEDA (n = 31) had significantly higher frequencies of non-classical monocytes (NCMs) (6.1% vs 1.4%) and activated regulatory T cells (Tregs; 2.1% vs 1.6%) than those with evidence of disease activity (n = 8). The NCM frequency and NCMs to classical monocytes ratio (NCM/CM) positively correlated with activated Treg frequency and duration of NEDA. Co-culture assays demonstrated that NCMs could increase the frequency of activated Tregs and the expression of PD-L1, contributing to development of Tregs, was particularly high in NCMs from patients with NEDA. Collectively, NCMs contribute to stable remission in patients with RRMS, possibly by increasing activated Treg frequency. In addition, the NCM frequency and NCM/CM ratio had high predictive values for disease stability (AUC = 0.97 and 0.94, respectively), suggesting these markers are potential predictors of a long-term NEDA status in RRMS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monócitos / Linfócitos T Reguladores / Esclerose Múltipla Recidivante-Remitente Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monócitos / Linfócitos T Reguladores / Esclerose Múltipla Recidivante-Remitente Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article