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Genomic Insights and Synthetic Biology Applications of Marine Actinomycete Streptomyces griseoincarnatus HNS054.
Wang, Qinghua; Zhao, Jing; Liu, Zhaoyuan; Ding, Shaoxiong; Huang, Zhiyong; Chen, Jun.
Afiliação
  • Wang Q; State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, China.
  • Zhao J; Department of Marine Biological Science and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
  • Liu Z; State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, China.
  • Ding S; Department of Marine Biological Science and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
  • Huang Z; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University, Xiamen 361102, China.
  • Chen J; State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, China.
Int J Mol Sci ; 25(6)2024 Mar 08.
Article em En | MEDLINE | ID: mdl-38542100
ABSTRACT
The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to S. coelicolor M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Produtos Biológicos / Actinobacteria / Streptomyces coelicolor Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Produtos Biológicos / Actinobacteria / Streptomyces coelicolor Idioma: En Ano de publicação: 2024 Tipo de documento: Article