[Recent advances in the genetic etiology of central precocious puberty]. / éä¼ ç¼ºé·è´ä¸æ¢æ§æ§æ©çç
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Zhongguo Dang Dai Er Ke Za Zhi
; 26(3): 302-307, 2024 Mar 15.
Article
em Zh
| MEDLINE
| ID: mdl-38557384
ABSTRACT
Central precocious puberty (CPP) is a developmental disorder caused by early activation of the hypothalamic-pituitary-gonadal axis. The incidence of CPP is rapidly increasing, but the underlying mechanisms are not fully understood. Previous studies have shown that gain-of-function mutations in the KISS1R and KISS1 genes and loss-of-function mutations in the MKRN3, LIN28, and DLK1 genes may lead to early initiation of pubertal development. Recent research has also revealed the significant role of epigenetic factors such as DNA methylation and microRNAs in the regulation of gonadotropin-releasing hormone neurons, as well as the modulating effect of gene networks involving multiple variant genes on pubertal initiation. This review summarizes the genetic etiology and pathogenic mechanisms underlying CPP.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
/
MicroRNAs
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article