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Autologous Blood-Derived Products (ABDPs) for the Treatment of Chronic Wounds.
Fierro, Allegra L; Foley, Carolyn; Lagziel, Tomer; Lantis, John C.
Afiliação
  • Fierro AL; Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Foley C; University of Massachusetts Chan Medical School, Worcester, Massachusetts.
  • Lagziel T; Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Lantis JC; Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.
Surg Technol Int ; 44: 37-51, 2024 07 15.
Article em En | MEDLINE | ID: mdl-38563248
ABSTRACT
Autologous blood-derived therapies have emerged as a unique and promising treatment option for chronic wounds. From whole blood clots to spun-down clot constituents, these therapies are highly versatile and tend to have a lower cost profile, allow for point-of-service preparation, and inherently carry minimal to no risk of rejection or allergic reaction when compared to many alternative cellular and matrix-like products. Subsequently, a diversity of processing systems, devices, and kits have surfaced on the market for preparing autologous blood-derived products (ABDPs) and many have demonstrated preclinical and clinical efficacy in facilitating chronic wound healing. However, not all ABDPs are created equal, and the lack of standardization among product formulations and cell concentrations as well as varying complexities in preparation protocols has led to unreliable substrate viabilities and overall inconsistent conclusions on efficacy. Additionally, external factors, such as the ease of drawing blood, the health of a patient's blood, and the reimbursement landscape have dissuaded some practitioners from incorporating ABDPs into an algorithm of care for recalcitrant wounds. Here, we attempt to categorize ABDPs into "classes" and examine their efficacy, advantages, and limitations when used as both a primary therapy and an adjunct for treating chronic wounds as well as comment on some potential considerations that may help gear future product development and application.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cicatrização / Transfusão de Sangue Autóloga Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cicatrização / Transfusão de Sangue Autóloga Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article