Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus.
Nat Neurosci
; 27(5): 927-939, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38570661
ABSTRACT
An essential feature of neurons is their ability to centrally integrate information from their dendrites. The activity of astrocytes, in contrast, has been described as mostly uncoordinated across cellular compartments without clear central integration. Here we report conditional integration of calcium signals in astrocytic distal processes at their soma. In the hippocampus of adult mice of both sexes, we found that global astrocytic activity, as recorded with population calcium imaging, reflected past neuronal and behavioral events on a timescale of seconds. Salient past events, indicated by pupil dilations, facilitated the propagation of calcium signals from distal processes to the soma. Centripetal propagation to the soma was reproduced by optogenetic activation of the locus coeruleus, a key regulator of arousal, and reduced by pharmacological inhibition of α1-adrenergic receptors. Together, our results suggest that astrocytes are computational units of the brain that slowly and conditionally integrate calcium signals upon behaviorally relevant events.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Locus Cerúleo
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Astrócitos
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Sinalização do Cálcio
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Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article