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Ionic Liquid Coating-Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV.
Hamadani, Christine M; Mahdi, Fakhri; Merrell, Anya; Flanders, Jack; Cao, Ruofan; Vashisth, Priyavrat; Dasanayake, Gaya S; Darlington, Donovan S; Singh, Gagandeep; Pride, Mercedes C; Monroe, Wake G; Taylor, George R; Hunter, Alysha N; Roman, Gregg; Paris, Jason J; Tanner, Eden E L.
Afiliação
  • Hamadani CM; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Mahdi F; Department of BioMolecular Sciences, The University of Mississippi, University, MS, 38677, USA.
  • Merrell A; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Flanders J; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Cao R; Department of BioMolecular Sciences, The University of Mississippi, University, MS, 38677, USA.
  • Vashisth P; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Dasanayake GS; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Darlington DS; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Singh G; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Pride MC; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Monroe WG; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Taylor GR; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Hunter AN; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
  • Roman G; Department of BioMolecular Sciences, The University of Mississippi, University, MS, 38677, USA.
  • Paris JJ; Department of BioMolecular Sciences, The University of Mississippi, University, MS, 38677, USA.
  • Tanner EEL; Department of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Adv Sci (Weinh) ; 11(23): e2305484, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38572510
ABSTRACT
Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, the CNS acts as a latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cannot eradicate HIV, and given CNS infection, patients experience neurological deficits collectively referred to as "neuroHIV". Herein, the development of bioinspired ionic liquid-coated nanoparticles (IL-NPs) for in situ hitchhiking on red blood cells (RBCs) is reported, which enables 48% brain delivery of intracarotid arterial- infused cargo. Moreover, IL choline trans-2-hexenoate (CA2HA 12) demonstrates preferential accumulation in parenchymal microglia over endothelial cells post-delivery. This study further demonstrates successful loading of abacavir (ABC), an ART that is challenging to encapsulate, into IL-NPs, and verifies retention of antiviral efficacy in vitro. IL-NPs are not cytotoxic to primary human peripheral blood mononuclear cells (PBMCs) and the CA2HA 12 coating itself confers notable anti-viremic capacity. In addition, in vitro cell culture assays show markedly increased uptake of IL-NPs into neural cells compared to bare PLGA nanoparticles. This work debuts bioinspired ionic liquids as promising nanoparticle coatings to assist CNS biodistribution and has the potential to revolutionize the delivery of cargos (i.e., drugs, viral vectors) through compartmental barriers such as the blood-brain-barrier (BBB).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Infecções por HIV / Líquidos Iônicos / Nanopartículas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Infecções por HIV / Líquidos Iônicos / Nanopartículas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article