Role of Mast Cells in Eosinophilic Gastrointestinal Diseases.
Immunol Allergy Clin North Am
; 44(2): 311-327, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38575226
ABSTRACT
Mast cells play a central role in the pathogenesis of eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis. Their interactions with immune and structural cells, involvement in tissue remodeling, and contribution to symptoms make them attractive targets for therapeutic intervention. More is being discovered regarding the intricate interplay of mast cells and eosinophils. Recent studies demonstrating that depletion of eosinophils is insufficient to improve symptoms of EGIDs have raised the question of whether other cells may play a role in symptomatology and pathogenesis of EGIDs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Enterite
/
Eosinofilia
/
Esofagite Eosinofílica
/
Gastrite
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article