Changing structures, changing paradigms: NELF helps regulate paused or elongating RNA polymerase II.
Mol Cell
; 84(7): 1180-1182, 2024 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-38579674
ABSTRACT
Using cryo-EM and biochemical methods, Su and Vos1 discover an alternative NELF structural state that enables transcription and switches NELF-RNA polymerase II (RNAPII) compatibility with other RNAPII-associated factors that regulate pausing, elongation, termination, and transcription-coupled DNA repair.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
RNA Polimerase II
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article