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Having the cake and eating it? Clofazimine boosts immunotherapy while limiting side effects.
Kraehenbuehl, Lukas; Wolchok, Jedd D; Merghoub, Taha; Hirschhorn, Daniel.
Afiliação
  • Kraehenbuehl L; Pharmacology Program, Weill Cornell Graduate School, New York, NY, USA; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medical Center, New York, NY, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical Center, New York, NY, USA; Depart
  • Wolchok JD; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medical Center, New York, NY, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical Center, New York, NY, USA; Immun
  • Merghoub T; Pharmacology Program, Weill Cornell Graduate School, New York, NY, USA; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medical Center, New York, NY, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical Center, New York, NY, USA; Parker
  • Hirschhorn D; Pharmacology Program, Weill Cornell Graduate School, New York, NY, USA; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medical Center, New York, NY, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical Center, New York, NY, USA. Electr
Cancer Cell ; 42(5): 738-741, 2024 May 13.
Article em En | MEDLINE | ID: mdl-38579723
ABSTRACT
Combined immune checkpoint blockade (ICB) for cancer exhibits good efficacy in a subset of patients but also associates with immune-related adverse events. Xue et al. use an elegant drug screening strategy to identify the antimicrobial drug clofazimine as an agent that both potentiates ICB efficacy and decreases immune-related adverse events.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clofazimina / Imunoterapia / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clofazimina / Imunoterapia / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article