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Comorbid physical health burden of serious mental health disorders in 32 European countries.
Wienand, Dennis; Wijnen, Lena I; Heilig, Daniel; Wippel, Christoph; Arango, Celso; Knudsen, Gitte M; Goodwin, Guy M; Simon, Judit.
Afiliação
  • Wienand D; Department of Health Economics, Center for Public Health, Medical University of Vienna, Vienna, Austria dennis.wienand@meduniwien.ac.at.
  • Wijnen LI; Department of Health Economics, Center for Public Health, Medical University of Vienna, Vienna, Austria.
  • Heilig D; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
  • Wippel C; Department of Health Economics, Center for Public Health, Medical University of Vienna, Vienna, Austria.
  • Arango C; Department of Health Economics, Center for Public Health, Medical University of Vienna, Vienna, Austria.
  • Knudsen GM; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
  • Goodwin GM; Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.
  • Simon J; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
BMJ Ment Health ; 27(1)2024 Apr 05.
Article em En | MEDLINE | ID: mdl-38580438
ABSTRACT

BACKGROUND:

Mental health disorders (MHDs) are associated with physical health disparities, but underlying excess risk and health burden have not yet been comprehensively assessed.

OBJECTIVE:

To assess the burden of comorbid physical health conditions (PHCs) across serious MHDs in Europe.

METHODS:

We estimated the relative prevalence risk of PHCs associated with alcohol use disorders (AUD), bipolar disorder (BD), depressive disorders (DD) and schizophrenia (SZ) across working-age populations of 32 European countries in 2019 based on a targeted literature review. Excess physical health burden was modelled using population-attributable fractions and country-level prevalence data.

FINDINGS:

We screened 10 960 studies, of which 41 were deemed eligible, with a total sample size of over 18 million persons. Relative prevalence of PHCs was reported in 54%, 20%, 15%, 5% and 7% of studies, respectively, for SZ, DD, BD, AUD or mixed. Significant relative risk estimates ranged from 1.44 to 3.66 for BD, from 1.43 to 2.21 for DD, from 0.81 to 1.97 for SZ and 3.31 for AUD. Excess physical health burden ranged between 27% and 67% of the total, corresponding to 84 million (AUD), 67 million (BD), 66 million (DD) and 5 million (SZ) PHC diagnoses in Europe. A 1% reduction in excess risk assuming causal inference could result in two million fewer PHCs across investigated MHDs.

CONCLUSIONS:

This is the first comprehensive study of the physical health burden of serious MHDs in Europe. The methods allow for updates, refinement and extension to other MHDs or geographical areas. CLINICAL IMPLICATIONS The results indicate potential population health benefits achievable through more integrated mental and physical healthcare and prevention approaches.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Transtorno Bipolar / Alcoolismo Limite: Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Transtorno Bipolar / Alcoolismo Limite: Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article