Strategies to enhance the ability of nerve guidance conduits to promote directional nerve growth.
Biomed Eng Online
; 23(1): 40, 2024 Apr 06.
Article
em En
| MEDLINE
| ID: mdl-38582838
ABSTRACT
Severely damaged peripheral nerves will regenerate incompletely due to lack of directionality in their regeneration, leading to loss of nerve function. To address this problem, various nerve guidance conduits (NGCs) have been developed to provide guidance for nerve repair. However, their clinical application is still limited, mainly because its effect in promoting nerve repair is not as good as autologous nerve transplantation. Therefore, it is necessary to enhance the ability of NGCs to promote directional nerve growth. Strategies include preparing various directional structures on NGCs to provide contact guidance, and loading various substances on them to provide electrical stimulation or neurotrophic factor concentration gradient to provide directional physical or biological signals.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próteses e Implantes
/
Regeneração Nervosa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article