High-resolution multi-reflection time-of-flight mass spectrometer with atmospheric pressure interface.
Rapid Commun Mass Spectrom
; 38(11): e9742, 2024 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-38587140
ABSTRACT
RATIONALE Atmospheric pressure interface multi-reflection time-of-flight mass spectrometry (API-MRTOF-MS) has the potential to be a rapid and high-resolution analytical tool for versatile applications in chemistry, biology, environmental science, and medicine. METHODS:
The ions were reflected in a mass analyzer via electrostatic mirrors and folded flight path. Therefore, flight distances were significantly increased. The ion flight path of the API-MRTOF-MS was extended from meters to over 1 km, and the mass resolution was increased. Furthermore, the mass analysis could be completed at around 10 ms due to the rapid response of TOF-MS.RESULTS:
A high-resolution API-MRTOF-MS approach is successfully developed in this study. The mass resolution could achieve 116 050 (full widths at half maximum [FWHM]) for Cs+ ions using an atmospheric pressure electrospray ionization within a total TOF of only 18 ms. An ion transmission efficiency of over 50% was achieved after 600 cycles.CONCLUSIONS:
The analytical performance of the newly developed API-MRTOF-MS demonstrated that it is suitable for high resolution and rapid analysis in many fields.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article