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Comparative analysis of glymphatic system alterations in multiple sclerosis and neuromyelitis optica spectrum disorder using MRI indices from diffusion tensor imaging.
Kim, Minchul; Hwang, Inpyeong; Park, Jung Hyun; Chung, Jin Wook; Kim, Sung Min; Kim, Ji-Hoon; Choi, Kyu Sung.
Afiliação
  • Kim M; Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Hwang I; Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
  • Park JH; Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea.
  • Chung JW; Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
  • Kim SM; Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea.
  • Kim JH; Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
  • Choi KS; Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
Hum Brain Mapp ; 45(5): e26680, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38590180
ABSTRACT

OBJECTIVE:

The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance. Glymphatic system dysfunction has been observed in both multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), indicating the role of neuroinflammation in the glymphatic system. However, little is known about how the two diseases differently affect the human glymphatic system. The present study aims to evaluate the diffusion MRI-based measures of the glymphatic system by contrasting MS and NMOSD.

METHODS:

This prospective study included 63 patients with NMOSD (n = 21) and MS (n = 42) who underwent DTI. The fractional volume of extracellular-free water (FW) and an index of diffusion tensor imaging (DTI) along the perivascular space (DTI-ALPS) were used as indirect indicators of water diffusivity in the interstitial extracellular and perivenous spaces of white matter, respectively. Age and EDSS scores were adjusted.

RESULTS:

Using Bayesian hypothesis testing, we show that the present data substantially favor the null model of no differences between MS and NMOSD for the diffusion MRI-based measures of the glymphatic system. The inclusion Bayes factor (BF10) of model-averaged probabilities of the group (MS, NMOSD) was 0.280 for FW and 0.236 for the ALPS index.

CONCLUSION:

Together, these findings suggest that glymphatic alteration associated with MS and NMOSD might be similar and common as an eventual result, albeit the disease etiologies differ. PRACTITIONER POINTS Previous literature indicates important glymphatic system alteration in MS and NMOSD. We explore the difference between MS and NMOSD using diffusion MRI-based measures of the glymphatic system. We show support for the null hypothesis of no difference between MS and NMOSD. This suggests that glymphatic alteration associated with MS and NMOSD might be similar and common etiology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neuromielite Óptica / Sistema Glinfático / Esclerose Múltipla Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neuromielite Óptica / Sistema Glinfático / Esclerose Múltipla Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article