Genetic conflicts in budding yeast: The 2µ plasmid as a model selfish element.
Semin Cell Dev Biol
; 161-162: 31-41, 2024.
Article
em En
| MEDLINE
| ID: mdl-38598944
ABSTRACT
Antagonistic coevolution, arising from genetic conflict, can drive rapid evolution and biological innovation. Conflict can arise both between organisms and within genomes. This review focuses on budding yeasts as a model system for exploring intra- and inter-genomic genetic conflict, highlighting in particular the 2-micron (2µ) plasmid as a model selfish element. The 2µ is found widely in laboratory strains and industrial isolates of Saccharomyces cerevisiae and has long been known to cause host fitness defects. Nevertheless, the plasmid is frequently ignored in the context of genetic, fitness, and evolution studies. Here, I make a case for further exploring the evolutionary impact of the 2µ plasmid as well as other selfish elements of budding yeasts, discuss recent advances, and, finally, future directions for the field.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomycetales
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article