2D CAIPI accelerated 3D multi-slab diffusion weighted EPI combined with qModeL reconstruction for fast high resolution microstructure imaging.
Magn Reson Imaging
; 111: 57-66, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38599504
ABSTRACT
PURPOSE:
To develop acceleration strategies for 3D multi-slab diffusion weighted imaging (3D ms-DWI) for enabling applications that require simultaneously high spatial (1 mm isotropic) and angular (> 30 directions) resolutions.METHODS:
3D ms-DWI offers high SNR-efficiency, with the ability to achieve high isotropic spatial resolution, yet suffers from long scan-times for studies requiring high angular resolutions. We develop 6D k-q space acceleration strategies to reduce the scan-time. Specifically, we develop non-uniform 3D ky-kz under-sampling employing a shot-selective 2D CAIPI sampling approach. To achieve inter-shot phase-compensation, 2D navigators were employed that utilize the same CAIPI trajectory. An iterative model-based 3D multi-shot reconstruction was designed by incorporating phase into the forward encoding process. Additionally, the shot-selective non-uniform ky-kz CAIPI acceleration was randomized along the q-dimension. The 3D model-based multi-shot reconstruction is then extended to a joint reconstruction that simultaneously reconstructs all the q-space points, with the help of a spatial total variation and deep-learned q-space regularization.RESULTS:
The proposed reconstruction is shown to achieve adequate phase-compensation in both 2D CAIPI accelerated and additional ky-kz under-sampled cases. Using retrospective under-sampling experiments, we show that k-q accelerations close a factor of 12 can be achieved with a reconstruction error < 3% for both single and multi-shell data. This translates to a scan-time reduction by 3-fold for experiments with simultaneously high spatial and angular resolutions.CONCLUSION:
The proposed method facilitates the utilization of 3D ms-DWI for simultaneously high k-q resolution applications with close to 3× reduced scan-time.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Imageamento Tridimensional
/
Imagem de Difusão por Ressonância Magnética
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article