The effect of tamoxifen on estradiol, SHBG, IGF-1, and CRP in women with breast cancer or at risk of developing breast cancer: a meta-analysis of randomized controlled trials.
Exp Gerontol
; 191: 112431, 2024 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-38608792
ABSTRACT
BACKGROUND AND AIM:
The effects of tamoxifen on the serum levels of hormones and acute phase reactants have been studied previously, but study results have been inconsistent, especially in women with breast cancer. Hence, we conducted this meta-analysis of randomized controlled trials (RCTs) to try to clarify the effects of tamoxifen on estradiol, insulin-like growth factor 1 (IGF-1), sex hormone binding globulin (SHBG), and C-reactive protein (CRP) serum levels in women with breast cancer or at risk of developing breast cancer.METHODS:
Databases were systematically searched up to December 2023. The meta-analysis was generated through a random-effects model and is presented as the weighted mean difference (WMD) and 95 % confidence intervals (CI).RESULTS:
Nine publications were included in the present meta-analysis. The comprehensive findings from the random-effects model revealed an elevation in estradiol (WMD 13.04 pg/mL, 95 % CI 0.79, 25.30, p = 0.037) and SHBG levels (WMD 21.26 nmol/l, 95 % CI 14.85, 27.68, p = 0.000), as well as a reduction in IGF-1 (WMD -14.41 µg/L, 95 % CI -24.23, -4.60, p = 0.004) and CRP concentrations (WMD -1.17 mg/dL, 95 % CI -2.29, -0.05, p = 0.039) following treatment with tamoxifen in women with breast cancer or at risk of developing breast cancer, with no impact on IGFBP-3 levels (WMD 0.11 µg/mL, 95 % CI -0.07, 0.30, p = 0.240).CONCLUSION:
Tamoxifen administration seems to increase estradiol and SHBG levels and reduce CRP and IGF-1 levels in women with breast cancer or at risk of developing breast cancer. Further studies are needed to determine whether these changes have any clinical relevance.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tamoxifeno
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Neoplasias da Mama
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Proteína C-Reativa
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Globulina de Ligação a Hormônio Sexual
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Fator de Crescimento Insulin-Like I
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Ensaios Clínicos Controlados Aleatórios como Assunto
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Estradiol
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article