Single-cell transcriptomics dissecting the development and evolution of nervous system in insects.
Curr Opin Insect Sci
; 63: 101201, 2024 06.
Article
em En
| MEDLINE
| ID: mdl-38608931
ABSTRACT
Insects can display a vast repertoire of complex and adaptive behaviors crucial for survival and reproduction. Yet, how the neural circuits underlying insect behaviors are assembled throughout development and remodeled during evolution remains largely obscure. The advent of single-cell transcriptomics has opened new paths to illuminate these historically intractable questions. Insect behavior is governed by its brain, whose functional complexity is realized through operations across multiple levels, from the molecular and cellular to the circuit and organ. Single-cell transcriptomics enables dissecting brain functions across all these levels and allows tracking regulatory dynamics throughout development and under perturbation. In this review, we mainly focus on the achievements of single-cell transcriptomics in dissecting the molecular and cellular architectures of nervous systems in representative insects, then discuss its applications in tracking the developmental trajectory and functional evolution of insect brains.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Evolução Biológica
/
Análise de Célula Única
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Transcriptoma
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Insetos
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article