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Monitoring Pharmaceuticals and Personal Care Products in Healthcare Effluent Wastewater Samples and the Effectiveness of Drug Removal in Wastewater Treatment Plants Using the UHPLC-MS/MS Method.
Molnarova, Lucia; Halesova, Tatana; Tomesova, Daniela; Vaclavikova, Marta; Bosakova, Zuzana.
Afiliação
  • Molnarova L; Department of Analytical Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43 Prague, Czech Republic.
  • Halesova T; ALS Czech Republic, Na Harfe 223/9, 190 00 Prague, Czech Republic.
  • Tomesova D; ALS Czech Republic, Na Harfe 223/9, 190 00 Prague, Czech Republic.
  • Vaclavikova M; ALS Czech Republic, Na Harfe 223/9, 190 00 Prague, Czech Republic.
  • Bosakova Z; Department of Analytical Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43 Prague, Czech Republic.
Molecules ; 29(7)2024 Mar 27.
Article em En | MEDLINE | ID: mdl-38611760
ABSTRACT
A multi-residue UHPLC-MS/MS analytical method, previously developed for monitoring 52 pharmaceuticals in drinking water, was used to analyse these pharmaceuticals in wastewater originating from healthcare facilities in the Czech Republic. Furthermore, the methodology was expanded to include the evaluation of the effectiveness of drug removal in Czech wastewater treatment plants (WWTPs). Of the 18 wastewater samples analysed by the validated UHPLC-MS/MS, each sample contained at least one quantifiable analyte. This study reveals the prevalence of several different drugs; mean concentrations of 702 µg L-1 of iomeprol, 48.8 µg L-1 of iopromide, 29.9 µg L-1 of gabapentin, 42.0 µg L-1 of caffeine and 82.5 µg L-1 of paracetamol were present. An analysis of 20 samples from ten WWTPs revealed different removal efficiencies for different analytes. Paracetamol was present in the inflow samples of all ten WWTPs and its removal efficiency was 100%. Analytes such as caffeine, ketoprofen, naproxen or atenolol showed high removal efficiencies exceeding 80%. On the other hand, pharmaceuticals like furosemide, metoprolol, iomeprol, zolpidem and tramadol showed lower removal efficiencies. Four pharmaceuticals exhibited higher concentrations in WWTP effluents than in the influents, resulting in negative removal efficiencies warfarin at -9.5%, indomethacin at -53%, trimethoprim at -54% and metronidazole at -110%. These comprehensive findings contribute valuable insights to the pharmaceutical landscape of wastewater from healthcare facilities and the varied removal efficiencies of Czech WWTPs, which together with the already published literature, gives a more complete picture of the burden on the aquatic environment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Iopamidol / Cosméticos / Acetaminofen Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Iopamidol / Cosméticos / Acetaminofen Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article