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Advancements in understanding bacterial enteritis pathogenesis through organoids.
Wu, Zhengyang; Liu, Hongyuan; Wang, Xianli.
Afiliação
  • Wu Z; Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Liu H; Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Wang X; Shanghai Jiao Tong University School of Public Health, Shanghai, 200025, China. wangxianli@shsmu.edu.cn.
Mol Biol Rep ; 51(1): 512, 2024 Apr 15.
Article em En | MEDLINE | ID: mdl-38622483
ABSTRACT
Bacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn mortality. Despite advancements gained from current animal and cell models in improving our understanding of pathogens, their widespread application is hindered by apparent drawbacks. Therefore, more precise models are imperatively required to develop more accurate studies on host-pathogen interactions and drug discovery. Since the emergence of intestinal organoids, massive studies utilizing organoids have been conducted to study the pathogenesis of bacterial enteritis, revealing new mechanisms and validating established ones. In this review, we focus on the advancements of several bacterial pathogenesis mechanisms observed in intestinal organoid/enteroid models, exploring the host response and bacterial effectors during the infection process. Finally, we address the features that warrant additional investigation or could be enhanced in existing organoid models in order to guide future research endeavors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Bacterianas / Enterite Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Bacterianas / Enterite Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article