Plasmonic Imaging of Single DNA with Charge Sensitive Monolayer WS2.
ACS Sens
; 9(4): 2134-2140, 2024 04 26.
Article
em En
| MEDLINE
| ID: mdl-38626725
ABSTRACT
Imaging the surface charge of biomolecules such as proteins and DNA, is crucial for comprehending their structure and function. Unfortunately, current methods for label-free, sensitive, and rapid imaging of the surface charge of single DNA molecules are limited. Here, we propose a plasmonic microscopy strategy that utilizes charge-sensitive single-crystal monolayer WS2 materials to image the local charge density of a single λ-DNA molecule. Our study reveals that WS2 is a highly sensitive charge-sensitive material that can accurately measure the local charge density of λ-DNA with high spatial resolution and sensitivity. The consistency of the surface charge density values obtained from the single-crystal monolayer WS2 materials with theoretical simulations demonstrates the reliability of our approach. Our findings suggest that this class of materials has significant implications for the development of label-free, scanning-free, and rapid optical detection and charge imaging of biomolecules.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article