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Locations and structures of influenza A virus packaging-associated signals and other functional elements via an in silico pipeline for predicting constrained features in RNA viruses.
Beniston, Emma; Skittrall, Jordan P.
Afiliação
  • Beniston E; Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
  • Skittrall JP; Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
PLoS Comput Biol ; 20(4): e1012009, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38648223
ABSTRACT
Influenza A virus contains regions of its segmented genome associated with ability to package the segments into virions, but many such regions are poorly characterised. We provide detailed predictions of the key locations within these packaging-associated regions, and their structures, by applying a recently-improved pipeline for delineating constrained regions in RNA viruses and applying structural prediction algorithms. We find and characterise other known constrained regions within influenza A genomes, including the region associated with the PA-X frameshift, regions associated with alternative splicing, and constraint around the initiation motif for a truncated PB1 protein, PB1-N92, associated with avian viruses. We further predict the presence of constrained regions that have not previously been described. The extra characterisation our work provides allows investigation of these key regions for drug target potential, and points towards determinants of packaging compatibility between segments.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Montagem de Vírus / Biologia Computacional Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Montagem de Vírus / Biologia Computacional Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article