Outcome of fetal congenital pulmonary malformations: a systematic review and meta-analysis.
J Perinat Med
; 52(5): 457-466, 2024 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-38651628
ABSTRACT
OBJECTIVES:
To report the outcome of fetuses with a prenatal diagnosis of congenital lung malformation (CLM) diagnosed on ultrasound by performing a comprehensive assessment of these outcomes through a systematic review and meta-analysis. CONTENT CLMs are a heterogeneous group of anomalies that involve the lung parenchyma and its bronchovascular structures. Their presentation and evolution are variable, from entirely asymptomatic lesions with sonographic regression in utero to hydropic fetuses requiring fetal therapy, intrauterine death or neonatal morbidity. A systematic review was conducted in Medline, Embase and Cochrane databases including studies on fetuses with CLM diagnosed prenatally in order to report the in-utero natural history of these lesions. Thirty-nine studies (2,638 fetuses) were included in the final review.SUMMARY:
Regression/reduction in size of the lung lesion during pregnancy was reported in 31â¯% of cases, while its increase in 8.5â¯% of cases. Intra-uterine death complicated 1.5â¯% of pregnancies with fetal CLM, while neonatal and perinatal death were 2.2 and 3â¯%, respectively. Neonatal morbidity occurred in 20.6â¯% of newborns with CLM; 46â¯% had surgery, mainly elective. In fetuses with CLM and hydrops, fetal/perinatal loss occurred in 42â¯%. Assessment of the role of fetal therapy in improving the outcomes of pregnancies complicated by CLM was hampered by the small number of included cases and heterogeneity of type of interventions. OUTLOOK Fetuses with CLM prenatally diagnosed have a generally favorable outcome. Conversely, there is a low quality of evidence on the actual role of fetal therapy in improving the outcome of fetuses presenting with these anomalies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ultrassonografia Pré-Natal
Limite:
Female
/
Humans
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Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article