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Alteration of medial temporal lobe metabolism related to Alzheimer's disease and dementia with lewy bodies.
Kang, Sungwoo; Jeon, Seun; Lee, Young-Gun; Ye, Byoung Seok.
Afiliação
  • Kang S; Department of Neurology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
  • Jeon S; Metabolism-Dementia Research Institute , Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Lee YG; Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
  • Ye BS; Department of Neurology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. romel79@gmail.com.
Alzheimers Res Ther ; 16(1): 89, 2024 04 23.
Article em En | MEDLINE | ID: mdl-38654300
ABSTRACT

BACKGROUND:

Association of medial temporal lobe (MTL) metabolism with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) has not been evaluated considering their mixed disease (MD).

METHODS:

131 patients with AD, 133 with DLB, 122 with MD, and 28 normal controls (NCs) underwent neuropsychological tests, assessments for parkinsonism, cognitive fluctuation (CF), and visual hallucinations (VH), and 18F-fluorodeoxyglucose PET to quantify MTL metabolism in the amygdala, hippocampus, and entorhinal cortex. The effects of AD and DLB on MTL metabolism were evaluated using general linear models (GLMs). Associations between MTL metabolism, cognition, and clinical features were evaluated using GLMs or logistic regression models separately performed for the AD spectrum (NC + AD + MD), DLB spectrum (NC + DLB + MD), and disease groups (AD + DLB + MD). Covariates included age, sex, and education.

RESULTS:

AD was associated with hippocampal/entorhinal hypometabolism, whereas DLB was associated with relative amygdalar/hippocampal hypermetabolism. Relative MTL hypermetabolism was associated with lower attention/visuospatial/executive scores and severe parkinsonism in both the AD and DLB spectra and disease groups. Left hippocampal/entorhinal hypometabolism was associated with lower verbal memory scores, whereas right hippocampal hypometabolism was associated with lower visual memory scores in both the AD spectrum and disease groups. Relative MTL hypermetabolism was associated with an increased risk of CF and VH in the disease group, and relative amygdalar hypermetabolism was associated with an increased risk of VH in the DLB spectrum.

CONCLUSIONS:

Entorhinal-hippocampal hypometabolism and relative amygdala-hippocampal hypermetabolism could be characteristics of AD- and DLB-related neurodegeneration, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Temporal / Fluordesoxiglucose F18 / Doença por Corpos de Lewy / Tomografia por Emissão de Pósitrons / Doença de Alzheimer / Testes Neuropsicológicos Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Temporal / Fluordesoxiglucose F18 / Doença por Corpos de Lewy / Tomografia por Emissão de Pósitrons / Doença de Alzheimer / Testes Neuropsicológicos Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article