[Advances in the study of the actin nucleation factor Spire].
Sheng Li Xue Bao
; 76(2): 341-345, 2024 Apr 25.
Article
em Zh
| MEDLINE
| ID: mdl-38658382
ABSTRACT
There are three main classes of actin nucleation factors Arp2/3 complexes, Spire and Formin. Spire assembles microfilaments by nucleating stable longitudinal tetramers and binding actin to the growing end of the microfilament. As early as 1999, Wellington et al. identified Spire as an actin nucleating agent, however, over the years, most studies have focused on Arp2/3 and Formin proteins; there has been relatively less research on Spire as a member of the actin nucleating factors. Recent studies have shown that Spire is involved in the vesicular transport through the synthesis of actin and plays an important role in neural development. In this paper, we reviewed the structure, expression and function of Spire, and its association with disease in order to identify meaningful potential directions for studies on Spire.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
/
Actinas
/
Proteínas dos Microfilamentos
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article