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Age and sex influence antibody profiles associated with tuberculosis progression.
Davies, Leela R L; Wang, Chuangqi; Steigler, Pia; Bowman, Kathryn A; Fischinger, Stephanie; Hatherill, Mark; Fisher, Michelle; Mbandi, Stanley Kimbung; Rodo, Miguel; Ottenhoff, Tom H M; Dockrell, Hazel M; Sutherland, Jayne S; Mayanja-Kizza, Harriet; Boom, W Henry; Walzl, Gerhard; Kaufmann, Stefan H E; Nemes, Elisa; Scriba, Thomas J; Lauffenburger, Douglas; Alter, Galit; Fortune, Sarah M.
Afiliação
  • Davies LRL; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Wang C; Brigham and Women's Hospital, Boston, MA, USA.
  • Steigler P; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Bowman KA; Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Fischinger S; South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Hatherill M; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
  • Fisher M; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Mbandi SK; Brigham and Women's Hospital, Boston, MA, USA.
  • Rodo M; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Ottenhoff THM; South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Dockrell HM; South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Sutherland JS; South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Mayanja-Kizza H; South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Boom WH; Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
  • Walzl G; Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia.
  • Kaufmann SHE; Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia.
  • Nemes E; Department of Medicine and Department of Microbiology, Makerere University, Kampala, Uganda.
  • Scriba TJ; Tuberculosis Research Unit, Case Western Reserve University, Cleveland, OH, USA.
  • Lauffenburger D; Department of Science and Technology National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosc
  • Alter G; Max Planck Institute for Infection Biology, Berlin, Germany.
  • Fortune SM; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Nat Microbiol ; 9(6): 1513-1525, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38658786
ABSTRACT
Antibody features vary with tuberculosis (TB) disease state. Whether clinical variables, such as age or sex, influence associations between Mycobacterium tuberculosis-specific antibody responses and disease state is not well explored. Here we profiled Mycobacterium tuberculosis-specific antibody responses in 140 TB-exposed South African individuals from the Adolescent Cohort Study. We identified distinct response features in individuals progressing to active TB from non-progressing, matched controls. A multivariate antibody score differentially associated with progression (SeroScore) identified progressors up to 2 years before TB diagnosis, earlier than that achieved with the RISK6 transcriptional signature of progression. We validated these antibody response features in the Grand Challenges 6-74 cohort. Both the SeroScore and RISK6 correlated better with risk of TB progression in adolescents compared with adults, and in males compared with females. This suggests that age and sex are important, underappreciated modifiers of antibody responses associated with TB progression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Progressão da Doença / Anticorpos Antibacterianos / Mycobacterium tuberculosis Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: Africa Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Progressão da Doença / Anticorpos Antibacterianos / Mycobacterium tuberculosis Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: Africa Idioma: En Ano de publicação: 2024 Tipo de documento: Article