Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver.
Science
; 384(6694): 438-446, 2024 Apr 26.
Article
em En
| MEDLINE
| ID: mdl-38662831
ABSTRACT
Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in nutrient availability has remained unaddressed. Here, we found that sensory food perception rapidly induced mitochondrial fragmentation in the liver through protein kinase B/AKT (AKT)-dependent phosphorylation of serine 131 of the mitochondrial fission factor (MFFS131). This response was mediated by activation of hypothalamic pro-opiomelanocortin (POMC)-expressing neurons. A nonphosphorylatable MFFS131G knock-in mutation abrogated AKT-induced mitochondrial fragmentation in vitro. In vivo, MFFS131G knock-in mice displayed altered liver mitochondrial dynamics and impaired insulin-stimulated suppression of hepatic glucose production. Thus, rapid activation of a hypothalamus-liver axis can adapt mitochondrial function to anticipated changes of nutritional state in control of hepatic glucose metabolism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Percepção
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Mitocôndrias Hepáticas
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Proteínas Mitocondriais
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Dinâmica Mitocondrial
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Alimentos
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Gluconeogênese
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Glucose
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Fígado
/
Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article