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Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica.
Oyadomari, Yasumoto; Goto, Yasuyuki; Suganuma, Keisuke; Kawazu, Shin-Ichiro; Becking, Leontine E; Fusetani, Nobuhiro; Nakao, Yoichi.
Afiliação
  • Oyadomari Y; Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
  • Goto Y; Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
  • Suganuma K; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro 080-8555, Japan.
  • Kawazu SI; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro 080-8555, Japan.
  • Becking LE; Aquaculture & Fisheries Group, Wageningen University & Research, P.O. Box 338, Bode 32, 6700 AH Wageningen, The Netherlands.
  • Fusetani N; Naturalis Biodiversity Center, Darwinweg 2, 23333 CR Leiden, The Netherlands.
  • Nakao Y; Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Mar Drugs ; 22(4)2024 Apr 12.
Article em En | MEDLINE | ID: mdl-38667788
ABSTRACT
A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Glicosídeos / Leishmania Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Glicosídeos / Leishmania Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2024 Tipo de documento: Article